I also have a Pod Farm 2 platinum/Toneport DI box which I upgraded from the old GearBox collection.......now, all collecting dust after getting my Focusrite insterface. I also was disappointed with Line 6 and their dongle tactics.....I was really happy with the sounds and gui of PodFarm......easy to dial in a good sound. I enjoyed using the Tone Direct Monitoring (like Lawajava said) which had no latency and recorded all my guitar tones directly using this.
Anyway, after getting Amplitube 3, I'm very happy with the tones/amp collections and hassle free "no dongle" appraoch.......but, I still prefere the PodFarm gui to A3.
I'll probably might use the Toneport DI box on a second PC at somepoint (if there's proper driver support available).