I presently have 3 external 4TB hard drives. I back up to each of them on a rotation once a week. So one has the back up from 3 weeks ago etc.
I use Acronis. It takes about three clicks and the back up starts and shuts down the machine after it's done.
I back up everything. The system, all the internal drives in entirety (that means two). It's 3 clicks so no extra effort to do the whole thing.
I've recovered my environment from these backups about a dozen times over the years. It take a couple clicks to kick off a restore.
Ever had a situation where some pop up window inexplicably starts popping up? And you can't find where it's coming from? You can spend weeks or hours trying to find it or squash it. Or maybe something else has gone bad, or you've lost a good version of a song you're working on. About a dozen times I've restored using Acronis (a couple clicks to kick it off) and each time it's been such a relief.
P.S. I keep one back up hard drive off premise in case of the unexpected....