I can only think of 3 reasons something like this would happen.
First you got a virus of some sort. since your computer is not connected to the internet I doubt that is the case. but run a scan anyway. I don't think the plugin install would insert a virus. especially if you paid money for them. A corrupt partition is not likely to affect the time and date settings.
Second somebody who knows you got on your computer and played around. Once again highly unlikely but you never know.
Third some how your CMOS/BIOS was reset. If this is the case then re-formating your hard drive and installing your operating system won't change much. It will give you a lot of extra work. This seems to be the most logical solution to me.
It could be that your CMOS battery is dying but it is not totally dead. If the date is changed and the time is different and the reboot sequence is set to default, then this is more than likely a BIOS issue. a problem with the battery would be the first thing I look at. these batteries are cheap and I would just replace it.
As for not being able to read the USB thumb drive I would look at your USB settings in the bios screen. More then likely there is a default setting that changed something. Maybe that is preventing your computer from looking at certain files on your thumb drive. That is my best guess.
Be sure and check the thumb drive on a different computers to see if it works. I have had this issue before and as I recall during the troubleshooting process, I installed the program in question on another computer and then checked the usb stick to see if it would unlock the program. I discovered that even though the file was on the thumb drive it became corrupt and it would not unlock the program. See if it unlocks the program on another computer.