tomixornot
Should I be strict about plugging the audio interface only to the chipset supported USB 2 ports ?
Z97 motherboards that offer USB3.1 - the USB3.1 ports are provided via PCIe controller (3rd party).
Many audio/MIDI interfaces have issues when connected to 3rd-party USB3 controllers.
Liken the situation to using a non-TI chipset Firewire controller with a Firewire audio interface.
As to your question:
It depends on the specific audio interface... and the specific USB3 port.
Using Intel USB3 ports (controller integrated into the Intel chipset - Z77, Z87, Z97, Z170, X99) your odds of success are much higher.
BTW, If your motherboard has few/no USB2 ports:
Most motherboards have USB2 headers.
You can get a USB2 bracket (less than $10 - resides in an empty slot space) and connect that to one of the motherboard's USB2 headers.
This will provide a pair of Intel USB2 ports.