Question, I know that regular hard drives get less efficient at seek times, when they start to get full, does this happen with an SSD drive?  I'm thinking of moving some of my samples from my sample drive (traditional) to my SSD drive (boot).

Hey, Mat...
 
google for specifics but you should leave a bit (10%ish) of free space but as ssd's are random access, no performance drops occur.  I looked at a study of google server drives which validated this last year.
 
Just the other day I bought Albion 1 and ended up moving both Albion3 (iceni... awesome!) and the new Albion 1 onto my boot SSD, a 500 gig evo... works great!
 

I agree with v-man. In my research I did before i got into ssd I found that no performance issues exist like you will find when a mechanical HD gets over half full.

But to get maximum performance out of the ssd, you will have to alot a certain amount of the drive to "operational overhead." The best way to do this is with the software that comes with the ssd. Samsung's is considered the best right now.

So I should be safe leaving say 100gb free on a 500 gb harddrive.  That gives me about 200 gigs to fill!
 
I will probably put like Nexus and Superior Drummer etc over there.  My Orchestra stuff is just too big though till, I can get the 1tb ones.