I got a new mouse a week or so ago and it's taken some time to find the problem I didn't explicitly install the right driver for it. It was using some kinda Microsoft default. I ran it down using Latency Mon. 
 
After installing the driver all is well.
 
But I spent more than an hour trying to turn off plugins looking for the cause. grouping and disabling...
 
E to bypass and I didn't hear it... (just by chance)...
 
Man, it was killing me.
 
All better now.

Glad you got it fixed Geoff. I hate when the computer doesn't play nice. It robs me of my inspiration sometimes.

I swear, you think you're finally in the clear... you've seen it all... everything works and works all the time.
 
Then your mouse dies.
 
Couple of takes from last night...
http://stabilitynetwork.blob.core.windows.net/g-tunes/20140527_GPR_07_CatfishJohn.mp3
http://stabilitynetwork.blob.core.windows.net/g-tunes/20140527_GPR_09_JamesRiverBlues.mp3
 

Nice catch!
 
:-)