I know there are various options that folks have mentioned.
For anyone considering Acronis I'll just put in a good word for it. Super easy to use.
It has saved my bacon too many times to count. Weird stuff happens to a complicated set up like ours at times you least expect it or least can handle being hosed. Restoring from a recent Acronis backup is painless and very easy to do.
Never had an issue with it working with IK Multimedia software or anything that's on the hard drive(s) being backed up or restored from a backup.