I had a similar situation a couple months back, and have another now.
Back then, laptop dock and tracking room are feeding a mixer in listening room, both 25 foot runs. TR to LR balanced, Lap to LR not, tho I thought it was.
Had hum in LR, only when Lap interface was connected to Yamaha H50's. (Also had hum in the Yamahas.) It went away when I ran balanced cables Lap to LP. Key point, Lap faders down, muted, hum still present in LR with audio feed only from TR. Pull the Yamahas, interface or monitor end, hum goes away.
Current situation, 2 control room PCs, mixer, and monitor on normal house circuit. Interface and outboard racks both on dedicated circuit. Yesterday, signals from main DAW clean, hum with ancilliary PC audio. Because the interfaces are lightpiped together, I can monitor from the audio outs of either interface, regardless of where the current audio is sourced. Regardless of which side I listened from, primary clean, ancilliary w 60 cycle.
Today, the situation is exactly reversed.
I haven't chased this one out yet, because I know I have to get all units onto the dedicated circuit, and when I do, there may be no issue to correct, but the point is...most of the time, in my experience anyway, hum is most noticeable on the feed that is most responsible, however, in those two instances, the noise appears at one location, when the key element producing the hum is elsewhere.
By itself, this kind of thinking hurts my head, and adding intermittent tendancies, and wider cause and effect loops, I have to really bear down to work thru things like this, so I hope I'm not laying any of that on you.
If you have the new interface isolated except for monitors, chances are you have the lay of the noise land as you describe. If however, a conventional approach doesn't correct it, and you don't decide to RMA the interface w Focusrite right away, you might try monitor cables with the shield detached on one end, and or a lift between the two.
In my book, hardware failures purchase karmic hassle free operation during new equipment breakin for a period equal to or longer than the utilization denial imposed by the original failure, but...
...Karma doesn't always read my report, or follow my recommendations.
Hope you clear your decks soon!
;-)