kitekrazy1
One of the biggest differences is the lack of 3rd party tutorials for Samplitude.
kitekrazy1 - Look
here.
To the OP: I bought Samplitude X3 Suite and Studio One 3 when Cakewalk folded last year. They are both terrific DAWs. It will depend on your personal style and preference, but you can't go wrong with either. Of course you have to understand it will take a while to get good at either of them, so you have to spend time on your decision. I can say this, if it helps: Samp is the geeky one, S1 tries to be simpler to use. (Full disclosure: I like geeky stuff.)