Things may have changed, but when I had a UX2, if I unplugged it to use my delta card, line 6 Pod farm did not function. If I recall correctly some of Gear box did but was very limited. Same now with the ilock version, it works as long as the ilock is connected.
Just so you know, I was pretty impressed with their support when I contacted them last year and I'm sure you would get a definitive answer from them. I have serious doubts there is a native version that is not protected by either ilock or their hardware, but perhaps they came to their senses and realized limiting their customers to folks that have certain pieces of hardware is really self defeating, but I doubt they see it that way.