Hey Grem, in all honesty, that project is really only if you enjoy such things... because of the pickups I chose, the tone variation is minimal (and could be easily compensated for with post-processing effects). I had chosen DiMarzio D-Activator pickups which are incredibly clean and high output pickups, so even putting them in parallel isn't "big" because the neck is pretty strong. Ironically, when I first wired this years ago, I left a stock (crappy) pickup in the neck and put a PAF Pro in the bridge, with only the original 3-way switch. That setup actually had significantly more tone variation since the stock pickup was very warm and muddy, and the PAF Pro was more hot and clean. The stock pickup alone sounded very acoustic because it was not overly responsive to harmonics. I think if pickups are "matched" the wiring I did is more "just because" rather than it gains much.
Back to the emulation part, I played with the 4-5 sample offset region and when clean this is adequate, but running it through GR5 or TH2 brings back the fundamentals, and jacks the artificial harmonics through the roof (and the associate hiss). Post-EQ helps "some," but I think ideally that would have to be re-amped with a real amp to be usable. I will back off the comb filter a bit and try it with a real amp at some point, but for now, the amp sim option (for that range at least) is a bit nasty.