Too many great ones to remember.
How about:
Brian: What will they do to me?
Ben the Prisoner: Oh you'll probably get away with crucifixion.
Brian: CRUCIFIXION?
Ben the Prisoner: Yeah, first offense.
or
Reg: All right, but apart from the sanitation, medicine, education, wine, public order, irrigation, roads, the fresh water system and public health, what have the Romans ever done for us?
Attendee: Brought peace?
Reg: Oh, peace - shut up!
or
Adam: What are your qualifications?
Beetlejuice: Ah. Well... I attended Juilliard... I'm a graduate of the Harvard business school. I travel quite extensively. I lived through the Black Plague and had a pretty good time during that. I've seen the EXORCIST ABOUT A HUNDRED AND SIXTY-SEVEN TIMES, AND IT KEEPS GETTING FUNNIER EVERY SINGLE TIME I SEE IT... NOT TO MENTION THE FACT THAT YOU'RE TALKING TO A DEAD GUY... NOW WHAT DO YOU THINK? You think I'm qualified?