Overall I have not experienced buggy behaviour but there has been some strange happenings around saving or trying to save under a different name.
Rather than closing the project and re opening, try quitting the whole program first and then re open Mixbus again from scratch and re open the projcet. I have found that gets things back to normal again.
I also find that is the only way to change the buffer settings. You may need a higher setting too to stop it from falling over if you are pushing your system hard.
There were some plugs that did not play nice with it too and I have generally removed any from the scan. I found it better to make a special folder and only put a copy of the VST's in there you want to work with. Rescan again but only point to that folder. Then you will end up with a sane number of plugs preent. The Harrison ones and the ones you know work correctly and want to use.