Those bugs tend to get really miffed when you mess with their home....
As an electrician and alarm tech, I tend to run into red wasps in panels that are outside, and under the eves of buildings. I keep some wasp spray and WD-40 handy.
I recall one instance where we were installing a new service and needed to put a 2" pipe through the wall.... as soon as we started pounding on the cinder block to knock the hole, yellow jackets started coming out about 5 feet down from us. A radio call to the boss (I had not started my own business yet) and an exterminator showed up..... with a few cans of bug spray. He wanted us to beat on the wall while he sprayed them as they came out........ uhhhhh NO!
One of our guys used a 10' piece of conduit to stand back and beat the wall. And they started to come out. The guy ran out of spray and had to go to his shop to get more. He came back with a case and lined the cans up on the ground so he could grab as needed.
To make a long story short, he estimated there were 40,000 or more yellow jackets in that wall once he was able to get it open. The hive was up the wall and across several cavities. They had been there for some time.
we were able to work to complete the job with only minor distractions from the returning yellow jackets. The exterminator was stung several times as was the lineman in the bucket truck and both of the other guys on our crew were hit once each..... but they were also provoking the bees after the job was done.
I don't know if hornet, wasp and yellow jacket venom is similar to honey bee venom, but they are using bee venom to treat MS.
side note: In Charleston SC they paint their porch ceilings light blue. It's believed that the color keeps wasps from building nests under the roof..... they think it's the open sky or something.