Beeps, the problem you are having with the guitars mixing with drums etc depends on your eq and compression. What you're experiencing is the lack of compression and some frequency masking. Any time you find a bunch of instruments competing, it's just about always frequency masking and a need for more compression.
Compression keeps things tight as you know. This way nothing lashes out. I know you know this, but it's important to know how to compress these types of sounds because you need more than you might normally use. So much so, you're looking at being right near the edge to where it pumps and breathes. As soon as it does that, you back it down until the artifact goes away. 4:1 to 6:1 ratio depending on the sound.
Watch eq's here...especially low end. If you ever hear a compressor kicking on you, before you adjust that compressor, check to see if you have excessive low end ramping the compressor up. 8 times out of 10 we can control a guitar sound by simply high passing it and removing the low end push. This is huge! Guitars (as well as bass guitar) have less bass in them than you think. The low end you hear in a mix is the sum of the kick, the bass and the guitars. Nothing really has any excessive low end in it unless you are using bass drops or effects of that nature.
In a layering sense, the more compression you can use (as long as you don't hear artifacts) the cooler it will sound. One thing you will realize when you have it right is...you will NEVER drown out your drums or anything else. Meaning, you can make your guitars louder where you will hear the drums need to come up, but you will not make it so that the drums disappear and are inaudible.
The above last sentence holds a crap load of weight and should be observed by everyone. Masking makes instruments disappear. Proper eq and compression will NEVER make an instrument disappear. You will always hear every nuance even though the instrument may appear too low level wise.
This was one thing that taught me about a good mix. I had the chance to hear some professional multi-tracks from some of the friends I have in high places. They gave me these multi-tracks to familiarize myself with what good tracks sound like. What I noticed was, no matter how loud I made an instrument, I never lost anything from the others. There's a difference between being too low and being too masked.
Anytime you have to keep reaching for a fader, and then reaching for the other to hear it...then the one that you touched before, you are dealing with masking. When you have your eq curve right on your instruments, compression can be used in moderation. That said, if you need to use the compression for effect purposes, you REALLY gain ground here because the instruments are already where they need to be. The compression stops the transients from going astray which tightens up the mix, keeps everything audible and allows you an even louder mix if need be. So keep some of this in mind also. :)
Looking forward to hearing what you're working on...make sure to share something with us when you are ready. :)
-Danny