WD drives are the way to go but why so big? An OS boot drive should not be your recording or media storage drives. It should just hold the OS & programs.
I use a 250GB drive with a 40GB boot partition (I'm still on XP) for my DAW. It's got 25GB on it and 15GB free. With Win 7 or 8 I'd go with an 100 GB boot partition. The rest of the drive is just for data files & progam install files. My recording drive is a 10,000 RPM 36GB SCSI. I also have a 1TB media storage drive and 4 TB network server drive. Not to mention a 2TB USB3 backup drive and a couple of USB3 500GB portable drives.
What ever you do do not use Seagate drives! Not worth the risk.