Man, I'm always late to the threads I can actually contribute to.
If it's not to late, here's my take. Those amps run hot and a tube failure is not unlikely. A very common failure is a short between the filament supply, 6.3 vac and one of the high voltage DC elements like a screen grid. You get an internal short and blow a fuse. Another common failure is with the rectifiers. Sometimes the surge current is high enough that a diode will short. A shorted power supply cap will also blow fuses. There's many possible causes.
What I would do in this case is pull the power tubes and see if the amp still blows the fuse. If it doesn't blow the fuse then you've isolated the problem. Past that point you should take it to somebody that knows what they're doing. The pain of a high voltage shock is major, trust me. If you have an underlying heart condition you don't know about it truly could be fatal. IS your safety worth $60? And yes, even unplugged there are lethal voltage/current values stored in the power supply caps. I had one discharge on my finger and it burned a perfect little hole in it, just like somebody took a red hot pin and stabbed me.
I'd go with a private guy that knows what they're talking about. I've seen the caliber of tech's that stores hire for minimum wage. Funny enough, when I do a job and calculate the time and money, I often find that I'm working for $3-$4 per hour. Get somebody that really loves working on gear and has good ears.
Don't replace your tubes with Mesa branded tubes. They are usually Chinese and have nothing special going on. There's nothing wrong with them but they're overpriced.
Tung Sol, Gold Lion, Electro Harmonics and Sovtek are all the same company in Russia. JJ is eastern Europe. Ruby is a re-brander with high standards. Groove tubes is now a Fender company with not so high standards (IMO). The country that gave us Telefunken is now selling Chinese tubes under the TAD brand> they are very good and have some proprietary deals with China.
I'm about the only guy in my area that doesn't have a $60/hr standard fee. I actually do a complete service and all maintenance for around $60 plus parts for 2 output tubes. For 4 output tubes it's usually $75 - $100. If I run into a hard to find or intermittent problem it's my loss, but how can I expect the customer to pay for my lack of trouble shooting ability.
Good luck.