yeah.... I have heard that on occasion. Mostly, I have seen others complain about it as well. Some instances are worse than others.
If everything is real quiet, I can hear it from time to time. It doesn't always happen. Mostly I hear it in the laptop. I assume it is caused by the lappy working on several things at once.
For some reason, yesterday, I had a song playing back and everything I did on the (lappy) computer... click the mouse, open a new window, whatever, seemed to create a noise of some sort in the playback. Today, on a new boot, totally quiet.
Generally speaking though..... the system is dead quiet. Especially the desktop DAW, which is the main computer I use. If I get noise..... I shut it down and cold reboot it and the interface.
quick check: shut off the monitors and see if the noise is in the headphones direct from the sound card/interface. If it's only in the monitors, check the cables. If it's in the headphones, it's probably getting in on the mic cables or internally from the circuitry. That could be a harder thing to find and fix. BUT.... grab a different mouse, because some mice make a lot of noise, especially the wireless ones. If you have a wireless mouse, connect a wired one. You may have to forego the convenience of a wireless mouse when recording and mixing.