90+ % of the time when someone posts a problem with a Firewire audio interface, they're not using a TI chipset Firewire controller. You can read these forums and see several posts (saying the same basic thing) nearly every day.
In the majority of these cases, moving to a good TI chipset FW controller resolves the problem.
Note that if your machine is having multiple (other) issues, a TI chipset FW controller won't address/fix those problems, but it is without question the best place to start if you're looking for rock-solid performance.
If you're still having issues after installing the TI FW controller, then I'd have a look at your DPC latency.