I know this is an older thread, but I thought this info might be useful.
I use Guitar Rig 5 pro for all my guitar work, and of course I like to run it as close to real time as possible.
With Double Precision on, I was getting crackles occasionally on my lowest latency settings, but when I turned it off, it was perfectly smooth.
My system is a not so great AMD quad core build with the Athlon ii X4 631 processor (2.6ghz). and guitar rig seems to not multi thread very well (when monitoring, one cpu would be 50%+ while the others were below 5% most of the time). so for this application, gaining that bit of processing by turning it off was extremely useful, as it may be for anyone who runs vst amp sims or other similar effects.