Best hard disk setup for dual hard drives

What do people recommend as the best hard drive configuration in a PC with dual hard-drives?

Currently I have 2 hard drives with 2 partitions each - the 1st drive is C and D, the 2nd hard drive is E and F.

I have Windows on C, Sonar on E and the virtual memory file on F - I was always told to put the virtual memory file on a physically separate partition from Windows. However, I wondered if having the virtual mem file on the same hard drive as Sonar could be problematic from a crackles / pops point of view.