Ha! OK. You're the first person I've encountered with the same experience as me.
Can't speak to your SEM latency, unless it's just that - latency, possible ASIO settings or whatever. SEM works fine here.
But the Analog Lab 2 - that's what I'm seeing here as well. It loads and looks normal, and I can load patches and change controls and so on, but it's unresponsive to either MIDI input (which works with anything else I load, and I'm very far from a beginner with this stuff, so I'm quite positive it's not mis-routed or anything) or mouse clicks on its own keyboard. It works fine in standalone OR (and this is my workaround for the moment) sub-hosted in NI's Komplete Kontrol. But loaded on its own, no.
TO make this even stranger, it DID work - once. I don't know what I did differently - the only thing I can think of is that I updated Azslow's plugin (which I use to interface between Sonar and two old control surfaces - a NI Kore and an Alphatrack). And it worked, so I thought it was fixed. But after a reboot, it went back to the previous behaviour. Very strange.
EDIT - ps I opened a thread over at the Arturia forums and someone from the company was looking into it with me, but it was working on their test machines so he couldn't really help...
Are you by any chance running Azslow's control surface plugin? Just out of interest...