Amazing. That's the same mixer I have.
Simple;
My 6i6 and your 2i4 has 3/4 out so I use that to the mixer.
I have a Joe Meek pre amp which has 2 outputs so one goes to the mixer and one to the interface.
You could do the same with anything that can split an XLR cable.
But what you can do is run the headphone output of the 2i4 to a second channel of the mixer.
So in other words
2i4 1/2 out goes to studio monitors.
2i4 3/4 out goes to a stereo input of Mixer- 3/4 or 5/6 using standard patch cables
2i4 Headphone out goes to 7/8 stereo channel of mixer via 1/4TRS Y cable to 2x 1/4 or RCA
This is a standard cable available even in dollar stores. They come with 1/8" TRS but the 1/8" to 1/4" TRS adaptors are also common.
You use the mixers headphone jack,, this is bonus as it's much louder too.
Now turn the direct monitor control to "input"
You will now hear just the vocal input in channel 7/8 you can add the mixers reverb.
The playback level is now controlled by the other channel 3/ or 5/6
I'm not sure with yours what happens when you turn the big knob down. on mine the monitors are off but out 3/4 is still hot.