So I'm using Sonar tonight, and all is well, I close it down and come back to it later and it says there's no audio output device. Sure enough, the Quad Capture drivers are gone.  I switch to other driver types, let it scan, switch back to ASIO, apply, the Wave Profiler window comes up really quick and goes away.  My Rig Kontrol ASIO driver is there, and I can use the Quad Capture in other apps like foobar2000, but Sonar all of a sudden complains.  I've rebooted twice, don't know yet how to reinstall the auto-downloading QuadCapture drivers, but I'm willing to try, but I'm dead in the water here.
 
Windows 10, latest update, trying to update to Lexington just in case, but Command Center is hanging and crashing.
(Edit: the thread on Command Center got the update in, but now Sonar won't even start.  It just hangs on the splash screen.)
(Edit: after a reboot, Sonar started, seems working now, and drivers are loading after reboot with the device detached.)

The command center fix is here http://forum.cakewalk.com/FindPost/3343751

Thanks, that got Lexington in, and I just got it up and running on the Quad Capture on the MME drivers and just switched to ASIO, and it appears to be working.
 
Edit: it went wonky again, and it appears now to be partly due to the USB cable. I suspect that during ASIO initialization something's not right, but it's sufficient for MME/WSAPI, etc., and it's been stable since replacing the cable.