The easiest way to move the Multisample folders (or most any other folder) is relocating them at the OS level and creating directory junctions to the new locations. For example, if the Rapture multisample folder is currently "C:\Program Files\Cakewalk\Rapture\Multisamples" and the new location is "S:\Samples\Rapture\MultiSamples", here are the steps to perform the task:
1. Using Windows Explorer move "C:\Program Files\Cakewalk\Rapture\Multisamples" to "S:\Samples\Rapture\MultiSamples"
2. Launch Windows cmd.exe
3. At the cmd prompt type
mklink /j "C:\Program Files\Cakewalk\Rapture\Multisamples" "S:\Samples\Rapture\MultiSamples" Another way to perform the relocation for Cakewalk synth samples only is through registry edits. The detailed are provided here
http://forum.cakewalk.com/FindPost/2673527 I prefer the mklink approach and it is a more general solution and does not mess with the registry. Both solutions can move data without the need to reinstall anything.