These files are huge and is making my nightly backups a lot bigger than they need to be. I've found no less than 3 sound folders for Dimesion Pro that are full of duplicates. Is there a registery change? Any ideas. Ideally I'd move them off to another disk for storing large, unchanging files.

I don't remember the details off the top of my head, but this question has been answered multiple times before. See, for example, "Moving the Dim Pro Sample Library To Another Drive" in the "Related Threads" below your post.

http://forum.cakewalk.com/FindPost/2673527
I prefer to use directory junctions instead of messing with the registry
There are quite a few threads about this. Use this search string in Google
site:forum.cakewalk.com scook mklink
to see some of the threads.

Thank you all!