itching itching itching

Peanut butter for the poo dam. And despite all the calories, it actually goes right through you as long as you eat it a couple of hours after your last meal of the day and don't eat anything with it like bread or crackers. Also, bananas. Just make sure they're very ripe. Green nanners clog you up; yellow nanners make you go.
 
Dr. Bill

Dear doctors  Evaluating your feedback  Bananas or even a garden hose up my ass better than how this stuff plugs you up
The itching still crazy They changed me to a drug called tramadol which is supposedly not a narcotic but has the pain relief of a narcotic This stuff is worse than morphine They can pump me up with steroids to bring down the welts and hives  I can scale off the narcotics in less than two weeks and just eat grocery store pills until they are not needed
Some advice  Never break your foot
 
XOX
Jyotishvarii
 

IIRC, Mooch had an itching problem sometime back and Bapu prescribed him a cream. Shirley, it must've resolved by now no?

Mesh no not resolved but if you can get me the formula for that cream
 
Starise I had a bad reaction some years ago with oxycodone after having a tooth pulled They put me on quick acting morphine this time that caused me to flare up in hives  I have no idea how anyone can get addicted to this poison but I need it or have myself convinced I need it for a few more days
I can share with you about sciatica that you can reverse the damage if not too chronic with a couple simple yoga postures practiced a couple times a day if this is not too culturally taboo to suggest
Search the net for the "head to knee" posture and the "spinal twist" posture This will take about a week to undo the stress causing sciatica and up to 2 or 3 months to heal the nerve damage  Better option than surgery and in the same line of approach as your chiropractor
 
Is pharmacy doctor John still around  He must have some concoction I can mix up in the sink or add to my shots of tequilla  Main complaints are insane itching that 50 mg of benadryl will not touch and bowels brought to a standstill This experience highlights to me just how much capacity the human body has to produce pain if something gets messed up or broken and how primitive we still are in controlling pain
 
Jyotishvarii

I hope you sued whoever let the brat swing on the clothes rack that caused your accident.  Kids today are so under supervised and the parents are often in Never-Never Land.  You shouldn't have to bear any financial loss because some idiot couldn't keep track of their brat.  I have no suggestions for your discomfort, but I just hope your pain meds are being well watched and regulated by your doctor.  That could lead to a whole other nightmare you don't need.
Best of luck!
John B

John
I related your advice to the doctor Unfortunately his response was "Crazy Pharmacist"
He explained that zofran has no effect on stopping the production of histamines or blocking their reaction  It would have no effect on itching plus the dose is twice the limit for its indicated use which is for nausea
Could you look this and were you maybe thinking nausea instead of itching
The doc said he could write for several days of the prednisone steroid if the itching and rash are unbearable.

Jyoti,
 
The doc is right that Zofran has nothing to do with the release or blocking of histamines.
The doc is wrong about Zofran's ineffectiveness to help with narcotic induced itching.
 
(That's my story and I'm stickin' to it)
 
The dose is not toxic at 8 mg. There may be a concern of prolonging the cardiac "QT interval" in people with certain heart disorders or concomitant meds that do the same. You can PM me with your medication list since don't want you to have to display your medical history on a public forum. If everything looks good and your heart is otherwise healthy, my completely off the record thought would be to give it a try. If you can borrow maybe 6 pills (4 mg each). Take 2 at a time (8 mg) every 4 hours. That should be enough time to see if it works for you. Remember I'm not an MD and can't advise you to do this legally and for your protection. Won't slit my wrists if you decide to go with the prednisone which will not cause too much damage over a few days.
 
Very best,
John
 
oh, and Starise...take the young lady's advice on the two movements she advised for sciatica.
 

I'm taking codeine based medicine on a regular basis for various pains. On the pharmacy they told me that there are some medicine to help with the connected constipation. I'm not so pro medicine so found another solution. A moderate amount of dry plums (2-3) pr day have worked for me. Also a tube of Enema ? (rectal fluid) can be helpful to loosen things up in an emergency. My sympathies, it's not fun ****ting bricks. 

Dear John
Thank you
Thank you
Thank you
Thank you
Thank you
Thank you
I have the "borrowed" bottle of ondansetron and followed your advice  In about three hours the rashes and itching started to subside. Not gone entirely but I have some quality of life back
I confessed my sins to the doctor and re asked for an rx for ondansetron
His first response was "Crazy Pharmacist"
He says that my relief is because of faith and placebo and he could do the same with M&M's if I believe  There is no connection between ondansetron and the histamine storm produced by narcotics
He said with a chuckle that he would entertain your argument if you have one but said that this is something you likely read off the back of a cereal box
He wants to know what medical evidence you have for this molecules and mechanisms  He wants to know what personal experience you have with this seeing it actually work  If convinced he will write a script for ondansetron
Dear crazy pharmacist give this guy hell for me if you can
Love you,
Jyotishvarii

Jyoti,
 
Please cut and paste between the quotes. Request to the doctor.
 
“Dear Doc,
 
I worked in a hospital setting for about 14 years and have ample experience with morphine induced itching. Inpatient, outpatient, hospice. The drug Zofran simply works although I don’t have every piece to the puzzle. We knew for many years that post surgical inpatients who presented with nausea also reported less narcotic itching. Much later we could trace back to the addition of Zofran on the pain protocols to control nausea. We used Zofran as a staple for intense itching in the later years. Oral dose was 8 mg every 4 hours scheduled (not prn). This was a godsend to many hospice patients. It works for most and well tolerated. I would estimate about 75 percent reduction on average.
 
You are correct that most narcotics will release histamines, but this is a minor part of the problem. Consider fentanyl which can cause itching and hives but has no effect on basophil degranulation. No histamines are released. Consider that administration of an opiate antagonist like naloxone resolves the itching as the drug is reversed. Consider that most antihistamines are of little value in controlling itch. Promethazine is the outlier but also modulates other neurotransmitters as well where the effect likely is.
 
Narcotic induced itching has a strong serotonergic component at the 5-HT3 receptor, and likely acetylcholine and norepinephrine are implicated (promethazine again).
 
You are aware of the various classes and subclasses of narcotic receptors.  Of interest is a mu 1 target located in the substantia gelatinosa  in the spinal cord dorsal horn. This structure is an isoform of the mu 1 receptor varying by a few amino acids in the chain. Close enough to be still classified as mu 1.
 
The isoform has dimerized with a gastrin releasing peptide receptor (GRPR). The dimer is called MOR1D. The GRPR segment has no ligand as far as I am aware but is activated by narcotic docking on the mu 1 isoform. The mu 1 pathway is devoid of the common G-protein cAMP reduction cascade leading to analgesia. GRPR circuit is ascending afferent. Where our knowledge at present falls short of the glory is that we really don’t know why this structure is there nor the fine details of the endpoint neural activations. MOR1D has one purpose, to cause itching.
 
Ample evidence is available in animal models with blocking the MOR1D and the reduction in scratching. Speculation is present that we will eventually design narcotics that interact with the other types of receptors but avoiding MOR1D. This will give us a narcotic analgesic virtually free of the itching side effect. Small quantities of an antihistamine may still be needed.
 
Currently, if we block 5-HT3, the majority of narcotic itching will begin to resolve within a few hours.
Thanks for considering this. I can elaborate on any questions or concerns you may have.
 
John Kenn, PharmD”
 
Jyoti,
 
The docs not wanting to give you Zofran has a legal part to it. He has to go “off label” to prescribe for itching and the dose is twice normal. He is protected if he gives you Zofran at the normal dose for nausea but it didn’t work and you missed girls night out at the bar because the nausea wasn’t fixed. Pain and suffering but you can’t sue him.  If he prescribed off label for itching and you showed up late to the bar because the itching wasn’t cured, you could take him down in court.
 
If you think this is happening, casually suggest that he can write the rx without indication, and for the standard dose. Then add “or as directed”.  Other point is to tell the doc you are experiencing nausea.
Please keep in touch and let the good folks here know how you are getting through this.
 
John
 
 

Jyoti,
A few scar decorations like a tattoo. Record of the blessings of going through life and surviving the experience. You will still be a beauty dancing on the bar counter top.
John

CBD oil?

I have a family member who swears by CBD oil for fibromyalgia, which I understand can be very painful. She doesn't use the off-the-shelf 100mg variety that you can get in health food stores. I believe she uses 800mg. She said it works very well for her.

Get well!

My understanding is that a lot of the CBD products are produced from plants with a very low THC content and/or produced in such a way to remove THC in order to reduce the psychoactive effects. 
 
The UK is the world's largest exporter of medicinal cannabis products, yet medicinal cannabis is not legal here.
 
The illegal, smoked variety helps me, or the some might say ...