Assuming it was sampled that way then yes it probably would. Well it depends what you are going for. However it probably won't make that much audible difference, it's all going to swim around in the mix one way or the other.
Think about how you would go about it if you were recording an actual orchestra. Would you close mic the whole orchestra, or would just stick a few mics in front of the players?
As far as reverbs are concerned for instance I would make sure all sounds are dry and put them all through the same reverb bus, I assuming here you are mainly doing one instrument at a time of course and your samples are dry(ish).
You would then "close mic" your soloists if you like as and when you please to bring out a performance (or play the instruments louder!)