OK... much has been said already on this.
Keep it as simple as you can.
The more complicated the rig and signal path, the harder it is to work efficiently.
Rip everything apart and start over.
new system: connect the interface to the DAW. (pretty much done at this point)
connect the mics and guitars to the interface for input
connect the studio monitoring to the interface outputs
use a mixer only if you need the preamps on mics or guitars..... hopefully the interface has nice pre's in it.
Record and mix 100% in the box.
I just described my rcording system..... except the mixer, because I do not have a mixing board. I operate 100% in the box with my system. It hardly even looks like a recording studio except for the Yamaha DX27S and guitar amp on the stands.
Check out the music I make with this simple rig.