When I record audio, especially guitars, I tend to intuitively want the chain to end with the amp sim going into the reverb, but where the other items fall is sort of a crap shoot for me. Are there circumstances where it will really matter where I put in the compressors, console emulators, saturation knobs and eq and such? 
 
I've been using the Breverb prochannel module a lot, so that locks me into doing the prochannel post-fx bin. Are there times when I don't want to do that?
 
Just curious. I'm really new here, and I want to steer away from the coin-toss decision tree.

A similar question was posted a couple of weeks ago:
 
How-do-you-order-your-PC-plugins
http://forum.cakewalk.com/m3167020.aspx
 
...and another one earlier:
 
Question-regarding-ideal-order-of-plugins
http://forum.cakewalk.com/m3130436.aspx
 
Some good responses in those two threads.

For guitar I gravitate toward starting the chain with some very light compression (1-2db) followed by a  HPF set to around 70-80Hz and LPF set to around 10-12KHz. Then the amp sim, then some heavier compression (I like Native Instrument's 1176 type compressor for this), then surgical EQ if required, followed by another EQ for color. 

There is a article on Premier Guitar this month that talks about getting out of the stompbox order standard paradigm.
 
The best advice is to experiment and see what sounds good.  Cause if it sounds good - it is good.

Kev999How-do-you-order-your-PC-plugins
http://forum.cakewalk.com/m3167020.aspx
 
Question-regarding-ideal-order-of-plugins
http://forum.cakewalk.com/m3130436.aspx

Thanks Kev. Great threads. 
 
And thanks Sharke. (taking notes...)

Great thread...thanks.